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作为模型视觉系统的斑马鱼。

The zebrafish as a model visual system.

作者信息

Bilotta J, Saszik S

机构信息

Department of Psychology and Biotechnology Center, Western Kentucky University, 1 Big Red Way, Bowling Green, KY 42101, USA.

出版信息

Int J Dev Neurosci. 2001 Nov;19(7):621-9. doi: 10.1016/s0736-5748(01)00050-8.

Abstract

The zebrafish has become an important vertebrate model in developmental neuroscience because it is a useful model for embryology, developmental biology, and genetic analysis. The similarities of its visual system to that of other vertebrates also make this animal a valuable model in vision science. The anatomical, physiological, and behavioral components of zebrafish visual processing have been studied in adult and in developing zebrafish. Its retinal anatomy continues to develop following hatching, providing an opportunity to correlate the development of retinal structure with visual physiology and behavior. In addition, a number of genetic mutations have been developed which are used to examine the contributions of genetics to visual development and function. This article will provide an overview of studies of zebrafish anatomical, physiological and behavioral processing, and the effects if genetic and environmental manipulations on visual development.

摘要

斑马鱼已成为发育神经科学中一种重要的脊椎动物模型,因为它是胚胎学、发育生物学和遗传分析的有用模型。其视觉系统与其他脊椎动物的相似性也使这种动物成为视觉科学中有价值的模型。斑马鱼视觉处理的解剖学、生理学和行为学组成部分已在成年斑马鱼和发育中的斑马鱼中进行了研究。其视网膜解剖结构在孵化后持续发育,为将视网膜结构的发育与视觉生理学和行为相关联提供了机会。此外,已经产生了一些基因突变,用于研究遗传学对视觉发育和功能的贡献。本文将概述斑马鱼解剖学、生理学和行为学处理的研究,以及遗传和环境操纵对视觉发育的影响。

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