石杉碱乙这种乙酰胆碱酯酶抑制剂的更强效类似物的合成。
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
作者信息
Rajendran V, Saxena Ashima, Doctor Bhupendra P, Kozikowski Alan P
机构信息
Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington DC 20007-2197, USA.
出版信息
Bioorg Med Chem Lett. 2002 Jun 3;12(11):1521-3. doi: 10.1016/s0960-894x(02)00204-4.
Abstract
The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.
摘要
报道了石杉碱乙类似物的合成及其乙酰胆碱酯酶抑制活性。这些新的外消旋类似物显示出比天然产物石杉碱乙更好的乙酰胆碱酯酶抑制活性。
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