Adeyemi O O, Okpo S O, Ogunti O O
Department of Pharmacology, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria.
Fitoterapia. 2002 Aug;73(5):375-80. doi: 10.1016/s0367-326x(02)00118-1.
The aqueous extract of Persea americana leaves produced a dose-dependent inhibition of both phases of formalin pain test in mice, a reduction in mouse writhing induced by acetic acid and an elevation of pain threshold in the hot plate test in mice. The extract also produced a dose-dependent inhibition of carrageenan-induced rat paw oedema. The results obtained indicate that the extract possesses analgesic and anti-inflammatory effects.
鳄梨叶水提取物对小鼠福尔马林疼痛试验的两个阶段均产生剂量依赖性抑制作用,能减轻乙酸诱导的小鼠扭体反应,并提高小鼠热板试验中的痛阈。该提取物还对角叉菜胶诱导的大鼠足跖水肿产生剂量依赖性抑制作用。所得结果表明该提取物具有镇痛和抗炎作用。