多胺代谢与癌症
Polyamine metabolism and cancer.
作者信息
Thomas Thresia, Thomas T J
机构信息
Department of Environmental & Community Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
出版信息
J Cell Mol Med. 2003 Apr-Jun;7(2):113-26. doi: 10.1111/j.1582-4934.2003.tb00210.x.
Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase. The catabolic enzymes include spermidine/spermine acetyltransferase, flavin containing polyamine oxidase, copper containing diamine oxidase, and possibly other amine oxidases. Multiple abnormalities in the control of polyamine metabolism and uptake might be responsible for increased levels of polyamines in cancer cells as compared to that of normal cells. This review is designed to look at the current research in polyamine biosynthesis, catabolism, and transport pathways, enumerate the functions of polyamines, and assess the potential for using polyamine metabolism or function as targets for cancer therapy.
多胺是存在于所有细胞中的脂肪族阳离子。在正常细胞中，多胺水平受到生物合成酶和分解代谢酶的复杂调控。生物合成酶包括鸟氨酸脱羧酶、S-腺苷甲硫氨酸脱羧酶、亚精胺合成酶和精胺合成酶。分解代谢酶包括亚精胺/精胺乙酰转移酶、含黄素的多胺氧化酶、含铜的二胺氧化酶，以及可能的其他胺氧化酶。与正常细胞相比，多胺代谢和摄取控制中的多种异常可能是癌细胞中多胺水平升高的原因。本综述旨在探讨多胺生物合成、分解代谢和转运途径的当前研究，列举多胺的功能，并评估将多胺代谢或功能用作癌症治疗靶点的潜力。
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