2004年的SCOP数据库：改进整合了结构和序列家族数据。
SCOP database in 2004: refinements integrate structure and sequence family data.
作者信息
Andreeva Antonina, Howorth Dave, Brenner Steven E, Hubbard Tim J P, Chothia Cyrus, Murzin Alexey G
机构信息
MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK.
出版信息
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D226-9. doi: 10.1093/nar/gkh039.
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are hierarchically classified into families, superfamilies, folds and classes. The continual accumulation of sequence and structural data allows more rigorous analysis and provides important information for understanding the protein world and its evolutionary repertoire. SCOP participates in a project that aims to rationalize and integrate the data on proteins held in several sequence and structure databases. As part of this project, starting with release 1.63, we have initiated a refinement of the SCOP classification, which introduces a number of changes mostly at the levels below superfamily. The pending SCOP reclassification will be carried out gradually through a number of future releases. In addition to the expanded set of static links to external resources, available at the level of domain entries, we have started modernization of the interface capabilities of SCOP allowing more dynamic links with other databases. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop.
蛋白质结构分类（SCOP）数据库是根据已知结构的所有蛋白质的进化和结构关系进行的全面排序。SCOP中的蛋白质结构域被分层分类为家族、超家族、折叠和类别。序列和结构数据的不断积累使得能够进行更严格的分析，并为理解蛋白质世界及其进化库提供重要信息。SCOP参与了一个项目，旨在使几个序列和结构数据库中保存的蛋白质数据合理化并进行整合。作为该项目的一部分，从1.63版本开始，我们对SCOP分类进行了细化，主要在超家族以下的级别引入了一些变化。即将进行的SCOP重新分类将通过未来的多个版本逐步实施。除了在结构域条目中提供的指向外部资源的扩展静态链接集之外，我们还开始对SCOP的接口功能进行现代化改造，以便与其他数据库进行更动态的链接。可通过http://scop.mrc-lmb.cam.ac.uk/scop访问SCOP。
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