女性性别发育途径：卵巢胚胎发育的当前知识
The pathway to femaleness: current knowledge on embryonic development of the ovary.
作者信息
Yao Humphrey Hung-Chang
机构信息
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, IL 61802, USA.
出版信息
Mol Cell Endocrinol. 2005 Jan 31;230(1-2):87-93. doi: 10.1016/j.mce.2004.11.003.
Abstract
Increasing evidence indicates that organogenesis of the ovary is not a passive process arising by default in the absence of the testis pathway. A coordinated interaction is actually in force between somatic cells and female germ cells in embryonic ovaries, thus creating a unique microenvironment that facilitates the formation of follicles. Identification of the functional roles of several novel regulatory elements such as Figalpha, Foxl2, follistatin, and Wnt4 reveals the complexity of early ovarian organization. Challenges await us to establish the molecular connections of these molecules as well as to discover new candidates in the pathway of early ovarian development.
摘要
越来越多的证据表明，卵巢的器官发生并非是在缺乏睾丸发育途径时默认出现的被动过程。实际上，胚胎卵巢中的体细胞与雌性生殖细胞之间存在着协同相互作用，从而形成了一个独特的微环境，有利于卵泡的形成。对Figalpha、Foxl2、卵泡抑素和Wnt4等几种新型调控元件功能作用的鉴定揭示了早期卵巢组织的复杂性。我们面临着诸多挑战，既要建立这些分子之间的分子联系，又要在早期卵巢发育途径中发现新的候选分子。
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本文引用的文献
1
Conserved patterns of gene expression in mice and goats in the vicinity of the Polled Intersex Syndrome (PIS) locus.
Chromosome Res. 2004;12(5):465-74. doi: 10.1023/B:CHRO.0000034746.46789.e0.
2
Germ cells enter meiosis in a rostro-caudal wave during development of the mouse ovary.
Mol Reprod Dev. 2004 Aug;68(4):422-8. doi: 10.1002/mrd.20105.
3
One tissue, two fates: molecular genetic events that underlie testis versus ovary development.
Nat Rev Genet. 2004 Jul;5(7):509-21. doi: 10.1038/nrg1381.
4
Molecular cloning and gene expression of Foxl2 in the Nile tilapia, Oreochromis niloticus.
Biochem Biophys Res Commun. 2004 Jul 16;320(1):83-9. doi: 10.1016/j.bbrc.2004.05.133.
5
Expression of P450 aromatase protein in developing and in sex-reversed gonads of the XX/XY type of the frog Rana rugosa.
Gen Comp Endocrinol. 2004 Jul;137(3):227-36. doi: 10.1016/j.ygcen.2004.03.013.
6
Oestrogens and temperature-dependent sex determination in reptiles: all is in the gonads.
J Endocrinol. 2004 Jun;181(3):367-77. doi: 10.1677/joe.0.1810367.
7
Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.
Dev Dyn. 2004 Jun;230(2):210-5. doi: 10.1002/dvdy.20042.
8
The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad.
Endocrinology. 2004 Aug;145(8):3950-60. doi: 10.1210/en.2003-1628. Epub 2004 May 13.
9
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development.
Hum Mol Genet. 2004 Jun 1;13(11):1171-81. doi: 10.1093/hmg/ddh124. Epub 2004 Mar 31.
10
The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.
Development. 2004 Feb;131(4):933-42. doi: 10.1242/dev.00969. Epub 2004 Jan 21.
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