预测辅助生殖技术妊娠结局的算法显示胚胎协同作用极小。

Algorithm to predict assisted reproductive technology pregnancy outcome reveals minimal embryo synergy.

作者信息

Torsky Sergey P, Amato Paula, Cisneros Pauline L, Sangi-Haghpeykar H, Trukhacheva Elena V, Carson Sandra A

机构信息

Baylor Assisted Reproductive Technology Program,Baylor College of Medicine, Houston, Texas.

出版信息

Fertil Steril. 2005 Mar;83(3):782-4. doi: 10.1016/j.fertnstert.2004.10.028.

DOI:10.1016/j.fertnstert.2004.10.028

PMID:15749519

Abstract

A mathematical model was developed to calculate the implantation probability for individual embryos based on the pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cases with multiple embryos transferred. This model was used to calculate implantation probabilities of embryos of 31 morphological types using the outcome of 1,200 IVF/ICSI cases. The algorithm was validated by comparing the calculated pregnancy probability and multiple pregnancy probability with the actual outcome of 281 separate IVF/ICSI cases. Finally, an estimation of embryo synergy was calculated.

摘要

开发了一种数学模型，用于根据移植多个胚胎的体外受精/卵胞浆内单精子注射（IVF/ICSI）病例的妊娠结局，计算单个胚胎的着床概率。该模型利用1200例IVF/ICSI病例的结局，计算了31种形态类型胚胎的着床概率。通过将计算出的妊娠概率和多胎妊娠概率与281例独立IVF/ICSI病例的实际结局进行比较，对该算法进行了验证。最后，计算了胚胎协同效应的估计值。