5-[¹²⁵I]碘-2'-脱氧尿苷与甲氨蝶呤在治疗晚期肿瘤性脑膜炎中的治疗潜力。

Therapeutic potential of 5-[125I]iodo-2'-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis.

作者信息

Kassis Amin I, Kirichian Agop M, Wang Ketai, Semnani Elham Safaie, Adelstein S James

机构信息

Harvard Medical School, Armenise Building, D2-137, 200 Longwood Avenue, Boston, MA 02115-5729, USA.

出版信息

Int J Radiat Biol. 2004 Nov-Dec;80(11-12):941-6. doi: 10.1080/09553000400017671.

DOI:10.1080/09553000400017671

PMID:15764406

Abstract

PURPOSE

To assess the therapeutic potential of methotrexate (MTX) and 5-[1251]liodo-2'-deoxyuridine (125IdUrd) administered sequentially in rats bearing advanced (ten-day-old) intrathecal (i.t.) TE671 human rhabdomyosarcoma tumours.

MATERIALS AND METHODS

Nude rats were injected with TE671 cells through an i.t. placed catheter. Ten days later, the animals were injected i.t. over a 12-day period with (i) saline daily, (ii) MTX every other day, (iii) 125IdUrd every other day, or (iv) MTX and 125IdUrd on alternating days. Onset of paralysis was determined as a function of time, and the medians for onset (M), percentage of cells killed (% kill), and log cell kill were calculated.

RESULTS

The data show that (i) injection of MTX leads to a moderate delay in the onset of paralysis (M(MTX) = 29 d versus Msaline = 20 d), (ii) administration of 125IdUrd is more effective (M(IdUrd) = 36 d), and (iii) sequential administration of MTX- 125IdUrd further increases the therapeutic efficacy of 125IdUrd (M(MTX)-IdUrd = 47 d).

CONCLUSIONS

Intrathecal injection of MTX-(125)IdUrd is efficacious in the therapy of advanced intrathecal tumours.

摘要

目的

评估甲氨蝶呤（MTX）和5-[¹²⁵I]碘-2'-脱氧尿苷（¹²⁵IdUrd）序贯给药对患有晚期（10日龄）鞘内注射（i.t.）TE671人横纹肌肉瘤肿瘤大鼠的治疗潜力。

材料与方法

通过鞘内放置的导管向裸鼠注射TE671细胞。10天后，在12天内对动物进行鞘内注射：（i）每日注射生理盐水，（ii）隔日注射MTX，（iii）隔日注射¹²⁵IdUrd，或（iv）MTX和¹²⁵IdUrd交替注射。根据时间确定麻痹的发作情况，并计算发作的中位数（M）、细胞杀伤百分比（%杀伤）和对数细胞杀伤。