化学遗传学：斑马鱼中的药物筛选。

Chemical genetics: Drug screens in Zebrafish.

作者信息

den Hertog Jeroen

机构信息

Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584, Utrecht, CT, The Netherlands.

出版信息

Biosci Rep. 2005 Oct-Dec;25(5-6):289-97. doi: 10.1007/s10540-005-2891-8.

DOI:10.1007/s10540-005-2891-8

PMID:16307377

Abstract

High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.

摘要

利用斑马鱼胚胎对具有特定生物活性的化合物进行全生物体高通量化学遗传筛选是可行的。迄今为止，至少已经开展了两项中大规模的药物筛选，从而鉴定出了干扰斑马鱼发育的化合物。利用斑马鱼胚胎进行化学遗传学研究可能会成为药物及其靶点发现过程中的重要一步。