新一代的JASPAR，即转录因子结合位点图谱的开放获取数据库。
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.
作者信息
Vlieghe Dominique, Sandelin Albin, De Bleser Pieter J, Vleminckx Kris, Wasserman Wyeth W, van Roy Frans, Lenhard Boris
机构信息
Department for Molecular Biomedical Research (DMBR), VIB-Ghent University, Technologiepark 927 B-9052, Ghent (Zwijnaarde), Belgium.
出版信息
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D95-7. doi: 10.1093/nar/gkj115.
JASPAR is the most complete open-access collection of transcription factor binding site (TFBS) matrices. In this new release, JASPAR grows into a meta-database of collections of TFBS models derived by diverse approaches. We present JASPAR CORE--an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JASPAR FAM--a collection of familial TFBS models and JASPAR phyloFACTS--a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes. JASPAR phyloFACTS serves as a non-redundant extension to JASPAR CORE, enhancing the overall breadth of JASPAR for promoter sequence analysis. The new release of JASPAR is available at http://jaspar.genereg.net.
JASPAR是转录因子结合位点（TFBS）矩阵最完整的开放获取集合。在这个新版本中，JASPAR发展成为一个通过多种方法衍生的TFBS模型集合的元数据库。我们展示了JASPAR CORE——原始的、基于高质量矩阵注释的非冗余转录因子结合谱集合的扩展版本，JASPAR FAM——家族TFBS模型集合，以及JASPAR phyloFACTS——一组从哺乳动物基因组中统计上过度表达、进化上保守的调控区域基序通过计算得出的矩阵。JASPAR phyloFACTS作为JASPAR CORE的非冗余扩展，增强了JASPAR用于启动子序列分析的整体广度。JASPAR的新版本可在http://jaspar.genereg.net获取。
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