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评估荟萃分析中的异质性:Q统计量还是I²指数?

Assessing heterogeneity in meta-analysis: Q statistic or I2 index?

作者信息

Huedo-Medina Tania B, Sánchez-Meca Julio, Marín-Martínez Fulgencio, Botella Juan

机构信息

Department of Basic Psychology & Methodology, University of Murcia, Murcia, Spain.

出版信息

Psychol Methods. 2006 Jun;11(2):193-206. doi: 10.1037/1082-989X.11.2.193.

Abstract

In meta-analysis, the usual way of assessing whether a set of single studies is homogeneous is by means of the Q test. However, the Q test only informs meta-analysts about the presence versus the absence of heterogeneity, but it does not report on the extent of such heterogeneity. Recently, the I(2) index has been proposed to quantify the degree of heterogeneity in a meta-analysis. In this article, the performances of the Q test and the confidence interval around the I(2) index are compared by means of a Monte Carlo simulation. The results show the utility of the I(2) index as a complement to the Q test, although it has the same problems of power with a small number of studies.

摘要

在荟萃分析中,评估一组单项研究是否具有同质性的常用方法是通过Q检验。然而,Q检验仅能告知荟萃分析者异质性的存在与否,却无法报告这种异质性的程度。最近,有人提出了I²指数来量化荟萃分析中的异质性程度。在本文中,通过蒙特卡洛模拟比较了Q检验和I²指数置信区间的性能。结果表明,I²指数可作为Q检验的补充,尽管在研究数量较少时它也存在与Q检验相同的功效问题。

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