Kosiborod Mikhail, Lichtman Judith H, Heidenreich Paul A, Normand Sharon-Lise T, Wang Yun, Brass Lawrence M, Krumholz Harlan M
Mid America Heart Institute of Saint Luke's Hospital, Kansas City, MO, USA.
Am J Med. 2006 Jul;119(7):616.e1-7. doi: 10.1016/j.amjmed.2005.11.019.
Despite dramatic changes in heart failure management during the 1990s, little is known about the national heart failure mortality trends during this time period, particularly among the elderly. The purpose of this study was to determine temporal trends in outcomes of elderly patients with heart failure between 1992 and 1999.
We analyzed a national sample of 3,957,520 Medicare beneficiaries aged 65 years or more who were hospitalized with heart failure between 1992 and 1999, assessing temporal trends in 30-day and 1-year all-cause mortality and 30-day and 6-month all-cause hospital readmission. In risk-adjusted analyses, mortality and readmission for each year between 1994 and 1999 were compared with the referent year of 1993.
Crude 30-day and 1-year mortality decreased slightly (range for 1992-1999: 11.0%-10.3% and 32.5%-31.7%, respectively), whereas 30-day and 6-month readmission increased (10.2%-13.8% and 35.4%-40.3%, respectively). After risk adjustment, there was no change in 30-day mortality between 1993 and 1999 (eg, for 1999 vs 1993, odds ratio [OR] 1.01, 95% confidence interval [CI], 1.00-1.02). One-year mortality was lower in 1994 compared with 1993 (OR 0.91, 95% CI, 0.90-0.92), but data from subsequent years suggested no continuous improvement after 1994 (1999 vs 1993: OR 0.93, 95% CI, 0.92-0.94). Thirty-day readmission increased (1999 vs 1993: OR 1.09, 95% CI, 1.07-1.10), but there was no change in 6-month readmission (1999 vs 1993: OR 1.00, 95% CI, 0.99-1.01).
We found no substantial improvement in mortality and hospital readmission during the 1990s among elderly patients hospitalized with heart failure. These findings suggest that recent innovations in heart failure management have not yet translated into better outcomes in this population.
尽管20世纪90年代心力衰竭的治疗发生了巨大变化,但对于这一时期全国心力衰竭死亡率的趋势,尤其是老年人中的趋势,人们了解甚少。本研究的目的是确定1992年至1999年间老年心力衰竭患者的预后随时间的变化趋势。
我们分析了1992年至1999年间因心力衰竭住院的3957520名65岁及以上医疗保险受益人的全国样本,评估30天和1年全因死亡率以及30天和6个月全因再入院率随时间的变化趋势。在风险调整分析中,将1994年至1999年每年的死亡率和再入院率与1993年的参照年份进行比较。
30天和1年的粗死亡率略有下降(1992 - 1999年范围:分别为11.0% - 10.3%和32.5% - 31.7%),而30天和6个月的再入院率有所上升(分别为10.2% - 13.8%和35.4% - 40.3%)。经过风险调整后,1993年至1999年间30天死亡率没有变化(例如,1999年与1993年相比,比值比[OR]为1.01,95%置信区间[CI]为1.00 - 1.02)。1994年的1年死亡率低于1993年(OR 0.91,95% CI为0.90 - 0.92),但随后几年的数据表明1994年后没有持续改善(1999年与1993年相比:OR 0.93,95% CI为0.92 - 0.94)。30天再入院率上升(1999年与1993年相比:OR 1.09,95% CI为1.07 - 1.10),但6个月再入院率没有变化(1999年与1993年相比:OR 1.00,95% CI为0.99 - 1.01)。
我们发现20世纪90年代因心力衰竭住院的老年患者在死亡率和医院再入院率方面没有实质性改善。这些发现表明,心力衰竭管理方面的近期创新尚未在这一人群中转化为更好的预后。