Coulthard P, Rolfe S, Mackie I C, Gazal G, Morton M, Jackson-Leech D
Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Manchester, UK.
Int J Oral Maxillofac Surg. 2006 Dec;35(12):1114-9. doi: 10.1016/j.ijom.2006.07.007. Epub 2006 Oct 2.
The aim of this study was to improve the pain experience for children following oral surgery under general anaesthesia. To this end, the efficacy and safety of intraoperative local anaesthetic (2% lidocaine with 1:200,000 epinephrine) for postoperative pain control was investigated. In a randomized controlled trial, 142 patients aged 12 years or less, who were scheduled for dental extractions under general anaesthesia, received local anaesthesia or saline intraoral injection after induction of anaesthesia. There was statistically no significant difference between groups for pain scores recorded preoperatively, on waking, at 30 min, at 24h, or for distress scores recorded preoperatively, on waking and at 30 min. 'Severe' pain scores were recorded for 13% of treatment and 12% of control patients and 'very severe' for 13% of treatment and 10% of control patients on waking. These rates were similar at 30 min but reduced at 24h. Lip/cheek biting injuries occurred in one control and three treatment patients. Intraoperative local anaesthesia has been found to be effective for pain control following a range of other surgical procedures, but we did not find it to be effective in reducing postoperative pain or distress in children after oral surgery. Reasons may include unfamiliarity with altered orofacial sensation.
本研究的目的是改善儿童在全身麻醉下进行口腔手术后的疼痛体验。为此,研究了术中局部麻醉(2%利多卡因加1:200,000肾上腺素)对术后疼痛控制的有效性和安全性。在一项随机对照试验中,142名12岁及以下计划在全身麻醉下拔牙的患者,在麻醉诱导后接受了局部麻醉或口腔内注射生理盐水。术前、苏醒时、30分钟时、24小时时记录的疼痛评分,以及术前、苏醒时和30分钟时记录的痛苦评分,两组之间在统计学上没有显著差异。苏醒时,13%的治疗组患者和12%的对照组患者记录为“重度”疼痛评分,13%的治疗组患者和10%的对照组患者记录为“极重度”疼痛评分。这些比率在30分钟时相似,但在24小时时降低。一名对照组患者和三名治疗组患者发生了唇/颊咬伤。已发现术中局部麻醉对一系列其他外科手术后的疼痛控制有效,但我们发现它对减轻儿童口腔手术后的术后疼痛或痛苦无效。原因可能包括对口腔面部感觉改变不熟悉。