脂肪细胞作为能量平衡和葡萄糖稳态的调节因子。
Adipocytes as regulators of energy balance and glucose homeostasis.
作者信息
Rosen Evan D, Spiegelman Bruce M
机构信息
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
出版信息
Nature. 2006 Dec 14;444(7121):847-53. doi: 10.1038/nature05483.
Abstract
Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance. Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity and metabolic diseases such as type 2 diabetes. Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions.
摘要
由于肥胖已成为一个严重的公共卫生问题，且人们认识到脂肪组织是各种生理途径的整合者，因此对脂肪细胞的研究力度日益加大。特别是，脂肪细胞在热量储存中的作用使其非常适合调节能量平衡。脂肪组织也是葡萄糖稳态的关键整合者。因此，了解脂肪细胞生物学对于理解肥胖和2型糖尿病等代谢疾病的病理生理基础至关重要。此外，合理调控脂肪生理学是治疗这些疾病的一个有前景的途径。
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