小鼠和人类对刚地弓形虫的细胞自主免疫。
Cell-autonomous immunity to Toxoplasma gondii in mouse and man.
作者信息
Könen-Waisman Stephanie, Howard Jonathan C
机构信息
Institute for Genetics, University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany.
出版信息
Microbes Infect. 2007 Nov-Dec;9(14-15):1652-61. doi: 10.1016/j.micinf.2007.09.005. Epub 2007 Sep 14.
PMID:18024121
Abstract
The protozoan, Toxoplasma gondii, is a natural pathogen of mouse and a zoonosis of man. Immunity against the pathogen is largely mediated by interferon-stimulated cell-autonomous mechanisms that are strikingly different between man and mouse. There are many poorly understood host and pathogen variables that affect the outcome of infection.
摘要
原生动物刚地弓形虫是小鼠的天然病原体，也是人类的一种人畜共患病原体。针对该病原体的免疫很大程度上由干扰素刺激的细胞自主机制介导，而人与小鼠的这种机制存在显著差异。有许多宿主和病原体变量尚未得到充分了解，这些变量会影响感染的结果。
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