中间宿主遗传背景对寄生虫传播动力学的影响：以曼氏血吸虫为例的案例研究
Effects of intermediate host genetic background on parasite transmission dynamics: a case study using Schistosoma mansoni.
作者信息
Zavodna Monika, Sandland Gregory J, Minchella Dennis J
机构信息
Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
出版信息
Exp Parasitol. 2008 Sep;120(1):57-61. doi: 10.1016/j.exppara.2008.04.021. Epub 2008 May 4.
Abstract
For parasites that require multiple hosts to complete their development, genetic interplay with one host may impact parasite transmission and establishment in subsequent hosts. In this study, we used microsatellite loci to address whether the genetic background of snail intermediate hosts influences life-history traits and transmission patterns of dioecious trematode parasites in their definitive hosts. We performed experimental Schistosoma mansoni infections utilizing two allopatric populations of Biomphalaria glabrata snails and assessed intensities and sex ratios of adult parasites in mouse definitive hosts. Our results suggest that the genetic background of hosts at one point in a parasite's life cycle can influence the intensities and sex ratios of worms in subsequent hosts.
摘要
对于需要多个宿主来完成其发育的寄生虫而言，与一个宿主的基因相互作用可能会影响寄生虫在后续宿主中的传播和定殖。在本研究中，我们使用微卫星基因座来探讨蜗牛中间宿主的基因背景是否会影响雌雄异体吸虫寄生虫在其终末宿主中的生活史特征和传播模式。我们利用两个异域分布的光滑双脐螺群体进行了曼氏血吸虫感染实验，并评估了小鼠终末宿主中成年寄生虫的感染强度和性别比例。我们的结果表明，寄生虫生命周期中某一阶段宿主的基因背景会影响后续宿主中虫体的感染强度和性别比例。
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