热量限制可延缓恒河猴疾病的发作和死亡。
Caloric restriction delays disease onset and mortality in rhesus monkeys.
作者信息
Colman Ricki J, Anderson Rozalyn M, Johnson Sterling C, Kastman Erik K, Kosmatka Kristopher J, Beasley T Mark, Allison David B, Cruzen Christina, Simmons Heather A, Kemnitz Joseph W, Weindruch Richard
机构信息
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
出版信息
Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.
热量限制（CR）在无营养不良的情况下，可延缓多种物种的衰老并延长寿命；然而，其对灵长类动物疾病抵抗力和死亡率的影响尚未明确。我们报告了一项针对恒河猴进行的为期20年的成年起病热量限制纵向研究结果，旨在填补衰老研究中的这一关键空白。在威斯康星国家灵长类动物研究中心饲养的一群恒河猴中，适度的热量限制降低了与衰老相关的死亡发生率。在报告的时间点，对照喂养的动物有50%存活，而热量限制组动物的存活率为80%。此外，热量限制延缓了与年龄相关的病理状况的发生。具体而言，热量限制降低了糖尿病、癌症、心血管疾病和脑萎缩的发生率。这些数据表明，热量限制可减缓灵长类动物的衰老。
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