比率型锌离子荧光传感器及基于比率型置换检测镉离子的新方法。

Ratiometric Zn2+ fluorescent sensor and new approach for sensing Cd2+ by ratiometric displacement.

作者信息

Xue Lin, Liu Qing, Jiang Hua

机构信息

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.

出版信息

Org Lett. 2009 Aug 6;11(15):3454-7. doi: 10.1021/ol901380w.

DOI:10.1021/ol901380w

PMID:19719190

Abstract

A fluorescent sensor QB, based on quinoline with DPA as receptor, is designed as a ratiometric sensor for Zn(2+) and CHEF (chelation enhanced fluorescence) sensor for Cd(2+). Moreover, another ratiometric signal output for Cd(2+) can be observed when the bound Zn(2+) in the QB-Zn(2+) complex is displaced by Cd(2+). These results demonstrate that QB can act not only as a ratiometirc sensor for Zn(2+) but also as a dual-mode Cd(2+)-selective sensor via the CHEF mechanism and ratiometric displacement.

摘要

一种基于喹啉并以二吡啶胺为受体的荧光传感器QB，被设计为用于锌离子（Zn(2+)）的比率传感器和用于镉离子（Cd(2+)）的螯合增强荧光（CHEF）传感器。此外，当QB-Zn(2+)络合物中结合的Zn(2+)被Cd(2+)取代时，还能观察到另一种针对Cd(2+)的比率信号输出。这些结果表明，QB不仅可以作为Zn(2+)的比率传感器，还可以通过CHEF机制和比率位移作为一种双模式Cd(2+)选择性传感器。