Cornejo-Esquerra Agustín, Talleri-de-Andrea Giancarlo, de Jesús Blanco-Favela José, Ramos-Mora Alberto, Villarán-Muñoz Benjamín
Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
Rev Med Inst Mex Seguro Soc. 2009 May-Jun;47(3):335-40.
Throughout history a diversity of therapeutic properties have been attributed to the leech Hirudo medicinalis, however, during the past twenty years its use has proven to be a practical and effective method for the relief of venous engorgement in reconstructive surgery. In Mexico this practice has been limited due to the lack of supply and to the time-consuming process of importation. Based on this need, the animal facilities of the Occidental Biomedical Research Center-IMSS in Guadalajara, Jalisco, has initiated a breeding and reproduction program of this species with the aim at improving its availability as a therapeutic device. The salivary gland of Hirudo medicinalis contains one of the most potent natural anticoagulants, known as hirudin, a histamine-like vasodilator, platelet aggregation inhibitors and highly specific proteases, all of which favor venous flow and turn this species into the most useful in the clinical setting. Nevertheless, it is important to know the potential risks of leech therapy since it has been associated with considerable morbidity when adequate precautions are not taken. This review exposes relevant aspects of the medicinal leech, the indications, mechanism of action and the protocol for this therapy.
纵观历史,医用水蛭(Hirudo medicinalis)被赋予了多种治疗特性,然而,在过去的二十年里,它已被证明是整形外科中缓解静脉充血的一种实用且有效的方法。在墨西哥,由于供应短缺和耗时的进口过程,这种做法受到了限制。基于这一需求,位于哈利斯科州瓜达拉哈拉市的西方生物医学研究中心 - 墨西哥社会保障局(Occidental Biomedical Research Center-IMSS)的动物设施已启动了该物种的繁殖计划,旨在提高其作为治疗工具的可获得性。医用水蛭的唾液腺含有一种最有效的天然抗凝剂,即水蛭素,一种组胺样血管扩张剂、血小板聚集抑制剂和高度特异性蛋白酶,所有这些都有利于静脉血流,并使该物种成为临床环境中最有用的物种。然而,了解水蛭疗法的潜在风险很重要,因为如果不采取适当的预防措施,它可能会导致相当高的发病率。本综述阐述了药用蛭的相关方面、适应症、作用机制以及该疗法的方案。