婴儿混合表型急性白血病（双系和双表型）伴 t(10;11)(p12;q23);MLL-MLLT10。
Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.
机构信息
Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9073, USA.
出版信息
Leuk Res. 2010 Aug;34(8):1107-9. doi: 10.1016/j.leukres.2010.02.029. Epub 2010 Mar 17.
We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.
我们报告了一例 6 个月大的男孩，患有混合表型急性白血病（MPAL），双系和双表型免疫表型（B 淋巴细胞系和联合 B 淋巴细胞系和单核细胞系），伴有 t(10;11)(p12;q23);MLL-MLLT10。他按照急性髓系白血病方案治疗，7 个月随访时完全缓解。据我们所知，这是首例报道的婴儿表现为 MPAL 的 MLL-MLLT10 重排病例。从临床实践的角度来看，该病例说明了检测 MLL 重排的重要性，因为它具有预后意义，流式细胞术免疫表型在诊断 MPAL 和监测微小残留病方面具有有效性。
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