后生动物中的端粒体生物学。
Telomere biology in Metazoa.
机构信息
Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9039, USA.
出版信息
FEBS Lett. 2010 Sep 10;584(17):3741-51. doi: 10.1016/j.febslet.2010.07.031. Epub 2010 Jul 23.
Abstract
In this review we present critical overview of some of the available literature on the fundamental biology of telomeres and telomerase in Metazoan. With the exception of Nematodes and Arthropods, the (TTAGGG)(n) sequence is conserved in most Metazoa. Available data show that telomerase-based end maintenance is a very ancient mechanism in unicellular and multicellular organisms. In invertebrates, fish, amphibian, and reptiles persistent telomerase activity in somatic tissues might allow the maintenance of the extensive regenerative potentials of these species. Telomerase repression among birds and many mammals suggests that, as humans, they may use replicative aging as a tumor protection mechanism.
摘要
在这篇综述中，我们对后生动物端粒和端粒酶的基础生物学的一些现有文献进行了批判性的概述。除了线虫和节肢动物外，大多数后生动物中都保守着（TTAGGG）（n）序列。现有数据表明，基于端粒酶的末端维持是单细胞和多细胞生物中非常古老的机制。在无脊椎动物、鱼类、两栖动物和爬行动物中，体细胞中端粒酶的持续活性可能允许这些物种维持广泛的再生潜力。鸟类和许多哺乳动物中端粒酶的抑制表明，它们可能像人类一样，将复制性衰老作为一种肿瘤保护机制。
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