多奈哌齐治疗对心血管死亡率的影响。
The effect of donepezil treatment on cardiovascular mortality.
机构信息
Department of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
Clin Pharmacol Ther. 2010 Sep;88(3):335-8. doi: 10.1038/clpt.2010.98. Epub 2010 Jul 21.
Abstract
The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer's disease and vascular dementia. Given acetylcholine's important actions on the heart, we undertook a retrospective cohort investigation to assess whether donepezil usage affects cardiovascular mortality. In patients treated with donepezil, hazard ratios for total and cardiovascular mortality were 0.68 (P = 0.045, 95% confidence interval 0.46-0.99) and 0.54 (P = 0.042, 95% confidence interval 0.30-0.98), respectively. The apparent survival benefit in donepezil-treated patients should not be overinterpreted. Prospective clinical trials are warranted.
摘要
盐酸多奈哌齐是一种乙酰胆碱酯酶抑制剂，可改善阿尔茨海默病和血管性痴呆患者的认知功能。鉴于乙酰胆碱对心脏的重要作用，我们进行了一项回顾性队列研究，以评估多奈哌齐的使用是否会影响心血管死亡率。在接受多奈哌齐治疗的患者中，全因死亡率和心血管死亡率的风险比分别为 0.68（P=0.045，95%置信区间 0.46-0.99）和 0.54（P=0.042，95%置信区间 0.30-0.98）。多奈哌齐治疗组患者的明显生存获益不应被过度解读。需要进行前瞻性临床试验。
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