氨酰-tRNA 合成酶的翻译后新功能。
New functions of aminoacyl-tRNA synthetases beyond translation.
机构信息
Min Guo, Xiang-Lei Yang and Paul Schimmel are at The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
Nat Rev Mol Cell Biol. 2010 Sep;11(9):668-74. doi: 10.1038/nrm2956. Epub 2010 Aug 11.
Abstract
Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation.
摘要
在进化过程中，真核氨酰-tRNA 合成酶（aaRSs）逐渐纳入与氨酰化反应没有本质联系的结构域和基序。这些结构域和基序几乎在所有 aaRSs 中的添加与真核生物的渐进进化和复杂性相关。基于最近的一些实验发现以及对 aaRS 蛋白质组的分析，我们提出它们是翻译以外的 aaRS 相关功能的标志物。
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