在中国湖南省，鉴定出两种新型的 OXA 型超广谱β-内酰胺酶 blaOXA-128 和 blaOXA-129，均存在于铜绿假单胞菌中。
Identification of blaOXA-128 and blaOXA-129, two novel OXA-type extended-spectrum-β-lactamases in Pseudomonas aeruginosa, in Hunan Province, China.
机构信息
Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
出版信息
J Basic Microbiol. 2010 Dec;50 Suppl 1:S116-9. doi: 10.1002/jobm.201000181.
We collected 97 non-repetitive carbapenemases-sensitive clinical isolates of Pseudomonas aeruginosa in Human Province, China, during the period of October 2006 to January 2007. From these isolates, we identified two novel oxacillin-hydrolysing (OXA) type extended-spectrum-β-lactamases (ESBLs): bla OXA-128 and bla OXA-129, which contain the mutations of I89V from bla OXA-56 and K134N from bla OXA-10, respectively. Clinical isolates containing either bla OXA-128 or bla OXA-129 show resistance to cephamycin-class antibiotics but sensitive to carbapenem-class antibiotics. The occurrence of novel OXA-type lactamases suggests a regional prevalent pattern of ESBLs Pseudomonas aeruginosa in this area.
我们于 2006 年 10 月至 2007 年 1 月期间在中国吉林省收集了 97 株非重复的对碳青霉烯类敏感的铜绿假单胞菌临床分离株。从这些分离株中，我们鉴定出两种新型的苯唑西林水解（OXA）型超广谱β-内酰胺酶（ESBL）：bla OXA-128 和 bla OXA-129，它们分别含有 bla OXA-56 的 I89V 突变和 bla OXA-10 的 K134N 突变。携带 bla OXA-128 或 bla OXA-129 的临床分离株对头孢菌素类抗生素表现出耐药性，但对碳青霉烯类抗生素敏感。新型 OXA 型内酰胺酶的出现表明该地区铜绿假单胞菌 ESBLs 存在区域性流行模式。
Zotero 插件