2009年甲型H1N1大流行性流感病毒血清学诊断方法的评估
Evaluation of serological diagnostic methods for the 2009 pandemic influenza A (H1N1) virus.
作者信息
Papenburg Jesse, Baz Mariana, Hamelin Marie-Ève, Rhéaume Chantal, Carbonneau Julie, Ouakki Manale, Rouleau Isabelle, De Serres Gaston, Boivin Guy
机构信息
Infectious Disease Research Center of the CHUQ-CHUL and Laval University, Quebec City, Quebec, Canada.
出版信息
Clin Vaccine Immunol. 2011 Mar;18(3):520-2. doi: 10.1128/CVI.00449-10. Epub 2011 Jan 12.
Abstract
Serology improves influenza diagnosis by capturing cases missed by reverse transcriptase PCR (RT-PCR). We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 influenza A (H1N1) virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance with RT-PCR (kappa = 0.69 versus kappa = 0.60) and greater sensitivity (83% versus 71%; P = 0.016).
摘要
血清学通过捕捉逆转录酶聚合酶链反应（RT-PCR）漏诊的病例来改善流感诊断。我们前瞻性地评估了2009年甲型H1N1流感病毒诊断的微量中和试验和血凝抑制试验，研究对象为24例经RT-PCR确诊的病例和98名家庭接触者。与血凝抑制试验相比，微量中和试验与RT-PCR的一致性更高（kappa值分别为0.69和0.60），敏感性也更高（分别为83%和71%；P = 0.016）。
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