[癌细胞与骨的相遇。癌症中的上皮-间质转化]
[Encounter of cancer cells with bone. Epithelial-mesenchymal transition in cancer].
作者信息
Horiguchi Kana, Saitoh Masao
机构信息
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
出版信息
Clin Calcium. 2011 Mar;21(3):405-10.
Acquisition of invasive phenotypes of cancer cells is one of the key steps to promote metastasis. It has been reported that fibroblastic cells are involved in enhancement of proliferation and invasion of cancer cells. Thus, it is important to know the molecular mechanisms of EMT (epithelial-mesenchymal transition) for developing diagnosis and cancer therapy. Since TGF-βis a key mediator of EMT and frequently expressed in various tumors, it may regulate not only the EMT of cancer cells as they acquire metastatic properties, but also the EMT of normal epithelial cells that are adjacent to tumors. In this review, we will discuss the EMT induced by TGF-β.
癌细胞侵袭性表型的获得是促进转移的关键步骤之一。据报道，成纤维细胞参与癌细胞增殖和侵袭的增强。因此，了解上皮-间质转化（EMT）的分子机制对于发展诊断和癌症治疗至关重要。由于转化生长因子-β（TGF-β）是EMT的关键介质且在各种肿瘤中频繁表达，它不仅可能在癌细胞获得转移特性时调节其EMT，还可能调节肿瘤邻近正常上皮细胞的EMT。在本综述中，我们将讨论由TGF-β诱导的EMT。
Zotero 插件