不对称有机催化吖嗪叶立德与甲基 2-(2-硝基苯基)丙烯酸酯的 1,3-偶极环加成反应，用于合成螺[色满并[3,4-b]吲哚]-1,3-二酮 A 的非对映异构体。
Asymmetic organocatalytic 1,3-dipolar cycloaddition of azomethine ylide to methyl 2-(2-nitrophenyl)acrylate for the synthesis of diastereoisomers of spirotryprostatin A.
机构信息
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
出版信息
Org Lett. 2011 May 6;13(9):2418-21. doi: 10.1021/ol200652j. Epub 2011 Apr 12.
PMID:21486026
Abstract
The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Brønsted acid.
摘要
已建立了两种立体异构体螺噁螺普罗汀 A 的全合成方法，该方法从 Brønsted 酸催化的甲基 2-(2-硝基苯基)丙烯酸酯与亚胺叶立德的不对称 1,3-偶极环加成反应开始。
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