四丁基氢氧化铵和甲醇促进的 4-芳基-2-甲基-3-丁炔-2-醇裂解制备末端芳基乙炔的快速高效合成路线。
A rapid and efficient synthetic route to terminal arylacetylenes by tetrabutylammonium hydroxide- and methanol-catalyzed cleavage of 4-aryl-2-methyl-3-butyn-2-ols.
机构信息
Department of Polymer Materials and Composites, School of Materials Science and Engineering, Beihang University, Beijing 100191, China.
出版信息
Beilstein J Org Chem. 2011 Apr 13;7:426-31. doi: 10.3762/bjoc.7.55.
Abstract
Tetrabutylammonium hydroxide with methanol as an additive was found to be a highly active catalyst for the cleavage of 4-aryl-2-methyl-3-butyn-2-ols. The reaction was performed at 55-75 °C and gave terminal arylacetylenes in good to excellent yields within several minutes. Compared with the usual reaction conditions (normally >110 °C, several hours), this novel catalyst system can dramatically decrease the reaction time under much milder conditions.
摘要
四丁基氢氧化铵和甲醇作为添加剂被发现是一种高效的催化剂，用于断裂 4-芳基-2-甲基-3-丁炔-2-醇。反应在 55-75°C 下进行，在几分钟内以良好到优异的收率得到末端芳基乙炔。与通常的反应条件（通常 >110°C，数小时）相比，该新型催化剂体系在更温和的条件下可以显著缩短反应时间。
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