RAS 和 Hedgehog——犯罪同伙。
RAS and Hedgehog--partners in crime.
机构信息
Institute of Molecular Biology and Tumor Research (IMT), Philipps University, 35037 Marburg, Germany.
出版信息
Front Biosci (Landmark Ed). 2011 Jun 1;16(6):2259-70. doi: 10.2741/3852.
DOI:10.2741/3852
PMID:21622175
Abstract
Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.
摘要
RAS 和 Hedgehog (HH) 信号通路的激活均可在大约三分之一的所有癌症中发现。在许多情况下，这种激活发生在相同的肿瘤类型中，这表明 RAS 和 HH 的同时激活对肿瘤的发展有积极影响。本综述旨在总结目前关于 RAS 和 HH 信号在过度增殖性疾病发展中的分子和功能串扰的知识。
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