piRNAs 和转座元件的发育功能：果蝇观点。
Developmental functions of piRNAs and transposable elements: a Drosophila point-of-view.
机构信息
mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, Montpellier, France.
出版信息
RNA Biol. 2011 Sep-Oct;8(5):754-9. doi: 10.4161/rna.8.5.16042. Epub 2011 Jul 19.
Abstract
The primary function of the piRNA pathway is to repress the expression and transposition of transposable elements. However, the piRNA pathway has additional biological and developmental functions. These functions are either a consequence of transposon regulation, or they result from direct roles of transposable elements in chromosome structure and gene regulation through piRNAs. Recent data have extended the functions of transposable elements in gene regulation, revealing a trans-acting role of transposable element piRNAs in the control of gene expression. Over the last few years, extensive studies on the piRNA pathway have rapidly increased our understanding of the relationships between transposable elements and the host genome, and of the essential role of transposable elements in biological and developmental processes.
摘要
piRNA 通路的主要功能是抑制转座元件的表达和转座。然而，piRNA 通路还有其他的生物学和发育功能。这些功能要么是转座子调控的结果，要么是转座元件通过 piRNA 直接参与染色体结构和基因调控的结果。最近的数据扩展了转座元件在基因调控中的功能，揭示了转座元件 piRNA 在控制基因表达中的反式作用。在过去的几年中，对 piRNA 通路的广泛研究极大地增进了我们对转座元件与宿主基因组之间关系的理解，以及转座元件在生物学和发育过程中的重要作用。
相似文献
1
Developmental functions of piRNAs and transposable elements: a Drosophila point-of-view.
RNA Biol. 2011 Sep-Oct;8(5):754-9. doi: 10.4161/rna.8.5.16042. Epub 2011 Jul 19.
2
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in male germline.
Genes Dev. 2021 Jun;35(11-12):914-935. doi: 10.1101/gad.345041.120. Epub 2021 May 13.
3
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.
Nature. 2010 Oct 28;467(7319):1128-32. doi: 10.1038/nature09465. Epub 2010 Oct 17.
4
Small RNA-directed silencing: the fly finds its inner fission yeast?
Curr Biol. 2013 Apr 22;23(8):R318-20. doi: 10.1016/j.cub.2013.03.033.
5
Natural variation of piRNA expression affects immunity to transposable elements.
PLoS Genet. 2017 Apr 27;13(4):e1006731. doi: 10.1371/journal.pgen.1006731. eCollection 2017 Apr.
6
Dual-layer transposon repression in heads of .
RNA. 2018 Dec;24(12):1749-1760. doi: 10.1261/rna.067173.118. Epub 2018 Sep 14.
7
piRNA-Guided Transposon Silencing and Response to Stress in Germline.
Viruses. 2024 Apr 30;16(5):714. doi: 10.3390/v16050714.
8
From Embryo to Adult: piRNA-Mediated Silencing throughout Germline Development in .
G3 (Bethesda). 2017 Feb 9;7(2):505-516. doi: 10.1534/g3.116.037291.
9
Reexamining the P-Element Invasion of Drosophila melanogaster Through the Lens of piRNA Silencing.
Genetics. 2016 Aug;203(4):1513-31. doi: 10.1534/genetics.115.184119.
10
piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire.
Genes Dev. 2015 Aug 15;29(16):1747-62. doi: 10.1101/gad.267252.115.
引用本文的文献
1
The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation.
Int J Mol Sci. 2023 Apr 21;24(8):7650. doi: 10.3390/ijms24087650.
2
Genome-wide profiling of piRNAs in the whitefly Bemisia tabaci reveals cluster distribution and association with begomovirus transmission.
PLoS One. 2019 Mar 12;14(3):e0213149. doi: 10.1371/journal.pone.0213149. eCollection 2019.
3
Transposable Elements in Human Cancer: Causes and Consequences of Deregulation.
Int J Mol Sci. 2017 May 4;18(5):974. doi: 10.3390/ijms18050974.
4
Developmental piRNA profiles of the invasive vector mosquito Aedes albopictus.
Parasit Vectors. 2016 Sep 29;9(1):524. doi: 10.1186/s13071-016-1815-8.
5
Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors.
Front Genet. 2014 Jun 10;5:172. doi: 10.3389/fgene.2014.00172. eCollection 2014.
6
Could interallelic interactions be a key to the epigenetic aspects of fitness-trait inbreeding depression?
Heredity (Edinb). 2014 Feb;112(2):219-20. doi: 10.1038/hdy.2013.80. Epub 2013 Oct 9.
7
The intertwining of transposable elements and non-coding RNAs.
Int J Mol Sci. 2013 Jun 26;14(7):13307-28. doi: 10.3390/ijms140713307.
8
Novel features of a PIWI-like protein homolog in the parasitic protozoan Leishmania.
PLoS One. 2012;7(12):e52612. doi: 10.1371/journal.pone.0052612. Epub 2012 Dec 21.
9
Protein interactions with piALU RNA indicates putative participation of retroRNA in the cell cycle, DNA repair and chromatin assembly.
Mob Genet Elements. 2012 Jan 1;2(1):26-35. doi: 10.4161/mge.19032.
10
Do human transposable element small RNAs serve primarily as genome defenders or genome regulators?
Mob Genet Elements. 2012 Jan 1;2(1):19-25. doi: 10.4161/mge.19031.
本文引用的文献
1
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.
Nat Genet. 2011 Feb;43(2):153-8. doi: 10.1038/ng.743. Epub 2010 Dec 26.
2
A role for vasa in regulating mitotic chromosome condensation in Drosophila.
Curr Biol. 2011 Jan 11;21(1):39-44. doi: 10.1016/j.cub.2010.11.051. Epub 2010 Dec 23.
3
Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection.
PLoS Genet. 2010 Dec 16;6(12):e1001246. doi: 10.1371/journal.pgen.1001246.
4
piRNAs, transposon silencing, and Drosophila germline development.
J Cell Biol. 2010 Nov 29;191(5):905-13. doi: 10.1083/jcb.201006034.
5
The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells.
J Biol Chem. 2011 Feb 4;286(5):3789-97. doi: 10.1074/jbc.M110.193888. Epub 2010 Nov 24.
6
Small RNA-mediated quiescence of transposable elements in animals.
Dev Cell. 2010 Nov 16;19(5):687-97. doi: 10.1016/j.devcel.2010.10.011.
7
Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis.
RNA. 2010 Dec;16(12):2503-15. doi: 10.1261/rna.2270710. Epub 2010 Oct 27.
8
Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.
Genes Dev. 2010 Nov 15;24(22):2499-504. doi: 10.1101/gad.1968110. Epub 2010 Oct 21.
9
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila.
Genes Dev. 2010 Nov 15;24(22):2493-8. doi: 10.1101/gad.1989510. Epub 2010 Oct 21.
10
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.
Nature. 2010 Oct 28;467(7319):1128-32. doi: 10.1038/nature09465. Epub 2010 Oct 17.
Zotero 插件