视网膜色素变性患者的视功能相关生活质量与微视野计测定的黄斑敏感性之间的关系。
Relationship between vision-related quality of life and microperimetry-determined macular sensitivity in patients with retinitis pigmentosa.
机构信息
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
出版信息
Jpn J Ophthalmol. 2011 Nov;55(6):643-6. doi: 10.1007/s10384-011-0080-9. Epub 2011 Aug 24.
PURPOSE
The aim of our study was to determine the relationship between vision-related quality of life (VRQOL) following the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) and the macular sensitivity determined by microperimetry in patients with retinitis pigmentosa (RP).
METHODS
The Japanese version of the NEI VFQ-25 was used to assess the VRQOL of 30 patients with typical RP whose decimal visual acuity was ≥0.6. The mean retinal sensitivity within the central 10° was determined by fundus-related microperimetry (MP1). The correlation between the mean of the total composite NEI VFQ-25 score and MP1-determined macular sensitivity was determined.
RESULTS
Mean NEI VFQ-25 score was 69.4 ± 14.5 (range 34.6-90.3) in RP patients. There was a significant positive correlation between mean NEI VFQ-25 score and mean retinal sensitivity within 10° (r = 0.673, P = 0.0003).
CONCLUSION
The significant correlation between macular sensitivity and VRQOL measured with the NEI VFQ-25 indicates that sensitivity in the macular area is an important consideration in using VRQOL with RP patients.
目的
本研究旨在确定经美国国家眼科研究所视觉功能问卷-25（NEI VFQ-25）评估的视功能相关生活质量（VRQOL）与色素性视网膜炎（RP）患者微视野计测量的黄斑敏感性之间的关系。
方法
使用日本版 NEI VFQ-25 评估 30 名典型 RP 患者的 VRQOL，这些患者的十进制视力≥0.6。通过眼底相关微视野计（MP1）确定中央 10°内的平均视网膜敏感性。确定总复合 NEI VFQ-25 评分的平均值与 MP1 确定的黄斑敏感性之间的相关性。
结果
RP 患者的平均 NEI VFQ-25 评分为 69.4±14.5（范围 34.6-90.3）。平均 NEI VFQ-25 评分与 10°内平均视网膜敏感性之间存在显著正相关（r=0.673，P=0.0003）。
结论
黄斑敏感性与 NEI VFQ-25 测量的 VRQOL 之间存在显著相关性，表明在使用 RP 患者的 VRQOL 时，黄斑区域的敏感性是一个重要的考虑因素。
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