中膜：血管壁的祖细胞龛位。
The adventitia: a progenitor cell niche for the vessel wall.
机构信息
Seattle Children's Research Institute, University of Washington, Seattle, Wash., USA.
出版信息
Cells Tissues Organs. 2012;195(1-2):73-81. doi: 10.1159/000331413. Epub 2011 Oct 14.
Abstract
Recent observations suggest that the adventitial layer of blood vessels exhibits properties resembling a stem/progenitor cell niche. Progenitor cells have been isolated from the adventitia of both murine and human blood vessels with the potential to form endothelial cells, mural cells, osteogenic cells, and adipocytes. These progenitors appear to cluster at or near the border zone between the outer media and inner adventitia. In the mouse, this border zone region corresponds to a localized site of sonic hedgehog signaling in the artery wall. This brief review will discuss the emerging evidence that the tunica adventitia may provide a niche-like signaling environment for resident progenitor cells and will address the role of the adventitia in growth, remodeling, and repair of the artery wall.
摘要
最近的观察表明，血管的血管外膜层表现出类似于干细胞/祖细胞龛的特性。已经从鼠类和人类血管的血管外膜中分离出祖细胞，这些祖细胞具有形成内皮细胞、壁细胞、成骨细胞和脂肪细胞的潜力。这些祖细胞似乎聚集在中膜和内血管外膜的交界处或附近。在小鼠中，这个交界区域对应于动脉壁中 sonic hedgehog 信号的局部位置。这篇简短的综述将讨论新兴的证据，即血管外膜可能为驻留祖细胞提供类似龛的信号环境，并将讨论血管外膜在动脉壁生长、重塑和修复中的作用。
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