转录作为基因组不稳定性的一个来源。
Transcription as a source of genome instability.
机构信息
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Nat Rev Genet. 2012 Feb 14;13(3):204-14. doi: 10.1038/nrg3152.
Abstract
Alterations in genome sequence and structure contribute to somatic disease, affect the fitness of subsequent generations and drive evolutionary processes. The crucial roles of highly accurate replication and efficient repair in maintaining overall genome integrity are well-known, but the more localized stability costs that are associated with transcribing DNA into RNA molecules are less appreciated. Here we review the diverse ways in which the essential process of transcription alters the underlying DNA template and thereby modifies the genetic landscape.
摘要
基因组序列和结构的改变会导致躯体疾病，影响后代的适应性，并推动进化过程。高度精确的复制和有效的修复在维持整体基因组完整性方面的关键作用是众所周知的，但人们对转录 DNA 为 RNA 分子所带来的更局部的稳定性成本认识不足。在这里，我们回顾了转录这一基本过程改变潜在 DNA 模板的多种方式，从而改变遗传景观。
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