印度慢性重金属暴露与胆囊癌风险：一项与日本的对比研究
Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan.
作者信息
Chhabra Deepak, Oda Koji, Jagannath Palepu, Utsunomiya Hirotoshi, Takekoshi Susumu, Nimura Yuji
机构信息
Department of Surgical Oncology, Lilavati Hospital and Research Centre, Mumbai, India.
出版信息
Asian Pac J Cancer Prev. 2012;13(1):187-90. doi: 10.7314/apjcp.2012.13.1.187.
BACKGROUND
High incidence of gallbladder cancer (GBC) is reported from North India, with elevated concentrations of heavy metals in water and soil. This Indo-Japan collaborative study compared presence of heavy metals in gallbladder tissues.
METHODS
Heavy metal concentrations were estimated in Indian GBC and cholecystitis tissues and compared with Japanese GBC and cholecystitis tissues. Spectrophotometry was done for 13 Indian gallbladder tissues (8 GBC, 5 cholecystitis) and 9 Japanese (5 GBC, 4 cholecystitis). Transmission electron microscopy (TEM) thin foil element analysis was done in 10 Indian samples (6 GBC, 4 cholecystitis).
RESULTS
Chromium, lead, arsenic and zinc were significantly high in Indian GBC compared with Japanese GBC. Chromium, lead and arsenic were significantly high in the Indian cholecystitis tissues compared to the Japanese. TEM of Indian tissues demonstrated electron dense deposits in GBC.
CONCLUSION
Heavy metals- chromium, lead, arsenic and zinc are potential carcinogens in Indian GBC from endemic areas. This preliminary study links presence of heavy metals in gallbladder cancer tissues in endemic areas.
背景
据报道，印度北部胆囊癌（GBC）的发病率很高，且水和土壤中的重金属浓度升高。这项印度 - 日本合作研究比较了胆囊组织中重金属的存在情况。
方法
对印度胆囊癌和胆囊炎组织中的重金属浓度进行了估算，并与日本胆囊癌和胆囊炎组织进行比较。对13份印度胆囊组织（8份胆囊癌，5份胆囊炎）和9份日本组织（5份胆囊癌，4份胆囊炎）进行了分光光度测定。对10份印度样本（6份胆囊癌，4份胆囊炎）进行了透射电子显微镜（TEM）薄箔元素分析。
结果
与日本胆囊癌相比，印度胆囊癌中的铬、铅、砷和锌含量显著更高。与日本相比，印度胆囊炎组织中的铬、铅和砷含量显著更高。印度组织的TEM显示胆囊癌中有电子致密沉积物。
结论
重金属——铬、铅、砷和锌是来自流行地区的印度胆囊癌中的潜在致癌物。这项初步研究将流行地区胆囊癌组织中重金属的存在联系了起来。
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