含透明质酸的雾化高渗盐水相较于单纯雾化高渗盐水可提高囊性纤维化肺病患者的耐受性：一项前瞻性、随机、双盲、对照研究。
Nebulized hypertonic saline containing hyaluronic acid improves tolerability in patients with cystic fibrosis and lung disease compared with nebulized hypertonic saline alone: a prospective, randomized, double-blind, controlled study.
机构信息
Ospedale dei Bambini 'Di Cristina' - Arnas Civico, U.O. II Pediatria per la Fibrosi Cistica (CRR) e le Malattie Respiratorie - Dcp/S. di Kartagener (CRR), Piazza Montalto , Palermo, Italy.
出版信息
Ther Adv Respir Dis. 2012 Dec;6(6):315-22. doi: 10.1177/1753465812458984. Epub 2012 Sep 11.
BACKGROUND
Hypertonic saline inhalation has been shown to be effective in patients with cystic fibrosis and lung disease. However, adverse events including marked airway narrowing are reported and a bronchodilator must be given before the administration of the product.
METHODS
We carried out a prospective, randomized, double-blind, parallel-group, controlled study of a hypertonic saline solution containing hyaluronic acid (Hyaneb) versus standard hypertonic saline therapy to assess whether the presence of hyaluronic acid would improve the tolerability of hypertonic saline.
RESULTS AND CONCLUSIONS
The results showed that nebulized Hyaneb was more effective in reducing the need for β(2) bronchodilators and caused a significant reduction in the incidence of adverse effects compared with nebulized hypertonic saline solution alone. Its safety profile indicates that Hyaneb can be used for the treatment of lung disease in cystic fibrosis.
背景
高渗盐水吸入已被证明对囊性纤维化和肺部疾病患者有效。然而，据报道会出现包括气道明显变窄在内的不良反应，在使用该产品之前必须给予支气管扩张剂。
方法
我们进行了一项前瞻性、随机、双盲、平行组、对照研究，比较了含有透明质酸的高渗盐水溶液（Hyaneb）与标准高渗盐水治疗，以评估透明质酸的存在是否会提高高渗盐水的耐受性。
结果和结论
结果表明，与单独使用高渗盐水雾化相比，雾化 Hyaneb 更有效地减少了对β(2)支气管扩张剂的需求，并显著降低了不良反应的发生率。其安全性特征表明，Hyaneb 可用于囊性纤维化的肺部疾病治疗。
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