Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Nat Rev Immunol. 2013 Feb;13(2):145-9. doi: 10.1038/nri3365.
Innate lymphoid cells (ILCs) are a family of developmentally related cells that are involved in immunity and in tissue development and remodelling. Recent research has identified several distinct members of this family. Confusingly, many different names have been used to characterize these newly identified ILC subsets. Here, we propose that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.
先天淋巴细胞 (ILC) 是一类在发育上相关的细胞,参与免疫以及组织发育和重塑。最近的研究已经确定了这个家族的几个不同成员。令人困惑的是,许多不同的名称被用来描述这些新鉴定的 ILC 亚群。在这里,我们建议根据它们能够产生的细胞因子以及调节其发育和功能的转录因子,将 ILC 分为三组。