着丝粒和动粒在染色体分离中的功能。
Functions of the centromere and kinetochore in chromosome segregation.
机构信息
Department of Biochemistry, Stanford University Medical School, Stanford, CA 94305, United States.
出版信息
Curr Opin Cell Biol. 2013 Jun;25(3):334-40. doi: 10.1016/j.ceb.2013.02.001. Epub 2013 Mar 13.
Abstract
Centromeres play essential roles in equal chromosome segregation by directing the assembly of the microtubule binding kinetochore and serving as the cohesion site between sister chromatids. Here, we review the significant recent progress in our understanding of centromere protein assembly and how centromere proteins form the foundation of the kinetochore.
摘要
着丝粒在指导微管结合动粒的组装和作为姐妹染色单体之间的黏合位点方面发挥着重要作用，从而实现染色体的均等分离。在这里，我们回顾了近年来人们对着丝粒蛋白组装的理解的重大进展，以及着丝粒蛋白如何构成动粒的基础。
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