不对称有机催化肉桂衍生物与稳定的锍叶立德的环丙烷化反应。
Asymmetric organocatalytic cyclopropanation of cinnamone derivatives with stabilized sulfonium ylides.
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
出版信息
J Org Chem. 2013 Jun 21;78(12):6322-7. doi: 10.1021/jo400743b. Epub 2013 Jun 10.
PMID:23718737
Abstract
A simple chiral diamine catalyst 1h was successfully applied in the asymmetric cyclopropanation of cinnamone derivatives with stabilized sulfur ylides. The desired cyclopropanation adducts were obtained in moderate yields (up to 68%) with good enantioselectivities (67-93% ee) and excellent diastereoselectivities (>95:5) under mild conditions.
摘要
一种简单的手性二胺催化剂 1h 成功地应用于肉桂酮衍生物与稳定的硫叶立德的不对称环丙烷化反应。在温和条件下，以中等收率（高达 68%）、良好的对映选择性（67-93%ee）和优异的非对映选择性（>95:5）获得了所需的环丙烷化加成产物。
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