2 型免疫与伤口愈合：寄生虫对适应性免疫的进化完善。
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.
机构信息
Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, State University of New Jersey, Newark, New Jersey 07103-2757, USA.
出版信息
Nat Rev Immunol. 2013 Aug;13(8):607-14. doi: 10.1038/nri3476. Epub 2013 Jul 5.
Abstract
Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.
摘要
寄生虫诱导的 2 型免疫反应的特征是与辅助性 T 细胞 2 相关的细胞因子白细胞介素-4（IL-4）和 IL-13，通过增强组织修复、控制炎症和驱蠕虫来介导宿主保护。在这篇观点文章中，我们将在寄生虫介导的组织损伤的背景下考虑 2 型免疫。我们研究了寄生虫感染控制与伤口修复机制之间的关系，并提供了对适应性 2 型免疫反应及其对宿主耐受和抵抗的贡献的新认识。
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