一种新的噻吩基吡唑啉荧光探针用于水溶液中的 Cu2+ 和活细胞成像。
A new thiophenyl pyrazoline fluorescent probe for Cu2+ in aqueous solution and imaging in live cell.
机构信息
School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, People's Republic of China.
出版信息
J Fluoresc. 2013 Nov;23(6):1263-9. doi: 10.1007/s10895-013-1259-x. Epub 2013 Jul 7.
A new thiophenyl pyrazoline probe for Cu(2+) in aqueous solution was synthesized and characterized by IR, NMR, HRMS and X-ray analysis. The probe displays remarkably high selectivity and sensitivity for Cu(2+) with a detection limit of 1.919 × 10(-7) M in aqueous solution (EtOH:HEPES = 1:1, v/v, 0.02 M, pH = 7.2). In addition, the probe is further successfully used to image Cu(2+) in living cells and the probe possesses good reversibility.
一种新的噻吩吡唑啉探针用于水溶液中的 Cu(2+)的合成和表征通过 IR、NMR、HRMS 和 X 射线分析。该探针对 Cu(2+)具有显著的高选择性和灵敏度，在水溶液中的检测限为 1.919×10(-7) M(EtOH:HEPES = 1:1，v/v，0.02 M，pH = 7.2)。此外，该探针进一步成功地用于活细胞中 Cu(2+)的成像，并且该探针具有良好的可逆性。
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