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[孕期药物、酒精摄入及吸烟情况与致畸风险评估]

[Consumption of medications, alcohol and smoking in pregnancy and assessment of teratogenic risks].

作者信息

Rocha Rebeca Silveira, Bezerra Samara Cavalcante, Lima José Welington de Oliveira, Costa Fabrício da Silva

机构信息

Universidade Estadual do Ceará (UECE), Fortaleza-CE, Brasil.

出版信息

Rev Gaucha Enferm. 2013 Jun;34(2):37-45. doi: 10.1590/s1983-14472013000200005.

Abstract

Medications, alcohol and smoking can cause fetal damage. A cross-sectional study was conducted with 326 mothers of the Fortaleza General Hospital to evaluate the use of drugs, alcohol and smoking during pregnancy and its relation to teratogenic potential in different population characteristics, between 2006 and 2007. Postpartum women who had their babies in the research site were included and those whose babies were not admitted as hospital inpatients were excluded. Chi-square tests and t-tests were used in the analysis, with a p value <0.05 considered significant. 96.6% of the mothers took medications (2.8 drugs/ pregnancy) and self-medication occurred in 11.3% of the cases. Single women took more drugs with high teratogenic potential (p=0.037). 11 cases of fetal malformation were observed, five of them were exposed to high teratogenic risks. Smoking occurred in 11.3% and alcohol use in 16%. Being single was found to be a risk factor for exposure to high teratogenic potential. Quality of prenatal care and other sociodemographic variables weren't related to exposure to teratogenic risks.

摘要

药物、酒精和吸烟会对胎儿造成损害。2006年至2007年期间,对福塔雷萨综合医院的326名母亲进行了一项横断面研究,以评估孕期药物、酒精和吸烟的使用情况及其与不同人群特征中致畸潜力的关系。纳入在研究地点分娩的产后妇女,排除其婴儿未作为住院患者入院的妇女。分析中使用了卡方检验和t检验,p值<0.05被认为具有统计学意义。96.6%的母亲服用过药物(每次怀孕服用2.8种药物),11.3%的病例存在自我用药情况。单身女性服用具有高致畸潜力药物的比例更高(p=0.037)。观察到11例胎儿畸形,其中5例暴露于高致畸风险中。11.3%的母亲吸烟,16%的母亲饮酒。单身被发现是暴露于高致畸潜力的一个风险因素。产前护理质量和其他社会人口统计学变量与致畸风险暴露无关。

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