Brd4 使染色质免受 ATM 激酶信号风暴的影响。
Brd4 shields chromatin from ATM kinase signaling storms.
机构信息
1UPMC Medical Education Transitional Year Residency Program, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Pittsburgh, PA 15213, USA.
出版信息
Sci Signal. 2013 Sep 17;6(293):pe30. doi: 10.1126/scisignal.2004622.
Abstract
Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.
摘要
激活后，共济失调毛细血管扩张突变（ATM）激酶迅速磷酸化数百种蛋白质，从受损染色质区域引发混乱的信号风暴。最近，Kaidi 和 Jackson 以及 Floyd 等人的工作推进了我们对在染色质处引发或限制 ATM 激酶信号风暴的机制的认识。
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