用于研究艰难梭菌感染和传播的鼠类模型。
Murine models to study Clostridium difficile infection and transmission.
机构信息
Bacterial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
出版信息
Anaerobe. 2013 Dec;24:94-7. doi: 10.1016/j.anaerobe.2013.09.008. Epub 2013 Sep 25.
Abstract
Clostridium difficile is the leading cause of antibiotic-associated diarrhea in healthcare facilities worldwide. C. difficile infections are difficult to treat because of the high rate of disease recurrence after antibiotic therapy, leaving few treatment options for patients. C. difficile is also difficult to contain within a healthcare setting due to a highly-transmissible, resistant spore form that challenges standard infection control measures. The recent development of murine infection models to study the interactions between C. difficile, the host and the microbiota are providing novel insight into the mechanisms of pathogenesis and transmission that should guide the development of therapies and intervention measures.
摘要
艰难梭菌是全球医疗保健机构中抗生素相关性腹泻的主要原因。由于抗生素治疗后疾病复发率高，艰难梭菌感染难以治疗，患者的治疗选择有限。由于具有高度传染性和耐药性的孢子形式，艰难梭菌在医疗环境中也难以控制，这给标准的感染控制措施带来了挑战。最近开发的用于研究艰难梭菌、宿主和微生物组之间相互作用的小鼠感染模型，为发病机制和传播机制提供了新的见解，这些见解应指导治疗和干预措施的开发。
相似文献
1
Murine models to study Clostridium difficile infection and transmission.
Anaerobe. 2013 Dec;24:94-7. doi: 10.1016/j.anaerobe.2013.09.008. Epub 2013 Sep 25.
2
Clinical characteristics of Clostridium difficile infection in hospitalized patients with antibiotic-associated diarrhea in a university hospital in China.
Eur J Clin Microbiol Infect Dis. 2014 Oct;33(10):1773-9. doi: 10.1007/s10096-014-2132-9. Epub 2014 May 13.
3
Small animal models for the study of Clostridium difficile disease pathogenesis.
FEMS Microbiol Lett. 2014 Mar;352(2):140-9. doi: 10.1111/1574-6968.12367. Epub 2014 Jan 7.
4
Clostridium difficile infection: toxins and non-toxin virulence factors, and their contributions to disease establishment and host response.
Gut Microbes. 2012 Mar-Apr;3(2):121-34. doi: 10.4161/gmic.19399. Epub 2012 Mar 1.
5
Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study.
Microbiol Spectr. 2022 Feb 23;10(1):e0132221. doi: 10.1128/spectrum.01322-21. Epub 2022 Jan 12.
6
A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network.
Microb Genom. 2019 Jul;5(7). doi: 10.1099/mgen.0.000271. Epub 2019 May 20.
7
Clostridium difficile infection in children hospitalized due to diarrhea.
Eur J Clin Microbiol Infect Dis. 2014 Feb;33(2):201-9. doi: 10.1007/s10096-013-1946-1. Epub 2013 Nov 10.
8
Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens.
Appl Environ Microbiol. 2010 Oct;76(20):6895-900. doi: 10.1128/AEM.00718-10. Epub 2010 Aug 27.
9
Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.
mBio. 2015 Jun 2;6(3):e00551. doi: 10.1128/mBio.00551-15.
10
The Clostridium difficile spo0A gene is a persistence and transmission factor.
Infect Immun. 2012 Aug;80(8):2704-11. doi: 10.1128/IAI.00147-12. Epub 2012 May 21.
引用本文的文献
1
in Animal Inflammatory Bowel Disease: A One Health Perspective on Emerging Zoonotic Threats.
Microorganisms. 2025 May 28;13(6):1233. doi: 10.3390/microorganisms13061233.
2
Prevention and cure of murine infection by a Lachnospiraceae strain.
Gut Microbes. 2024 Jan-Dec;16(1):2392872. doi: 10.1080/19490976.2024.2392872. Epub 2024 Aug 27.
3
Reviewing the Mouse Model: Insights into Infection Mechanisms.
Microorganisms. 2024 Jan 27;12(2):273. doi: 10.3390/microorganisms12020273.
4
Nonmammalian models to study Clostridioides difficile infection; a systematic review.
Anaerobe. 2023 Feb;79:102694. doi: 10.1016/j.anaerobe.2023.102694. Epub 2023 Jan 7.
5
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model.
Methods Mol Biol. 2022;2542:271-285. doi: 10.1007/978-1-0716-2549-1_20.
6
Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis.
mBio. 2022 Aug 30;13(4):e0190422. doi: 10.1128/mbio.01904-22. Epub 2022 Jul 28.
7
A High-Carbohydrate Diet Prolongs Dysbiosis and Clostridioides difficile Carriage and Increases Delayed Mortality in a Hamster Model of Infection.
Microbiol Spectr. 2022 Aug 31;10(4):e0180421. doi: 10.1128/spectrum.01804-21. Epub 2022 Jun 16.
8
The Initial Gut Microbiota and Response to Antibiotic Perturbation Influence Clostridioides difficile Clearance in Mice.
mSphere. 2020 Oct 21;5(5):e00869-20. doi: 10.1128/mSphere.00869-20.
9
Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization.
Nat Commun. 2020 Oct 9;11(1):5104. doi: 10.1038/s41467-020-18928-1.
10
Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota.
Anaerobe. 2020 Dec;66:102279. doi: 10.1016/j.anaerobe.2020.102279. Epub 2020 Oct 3.
本文引用的文献
1
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.
PLoS Pathog. 2012;8(10):e1002995. doi: 10.1371/journal.ppat.1002995. Epub 2012 Oct 25.
2
Antibiotics in early life alter the murine colonic microbiome and adiposity.
Nature. 2012 Aug 30;488(7413):621-6. doi: 10.1038/nature11400.
3
Suppression of Clostridium difficile in the gastrointestinal tracts of germfree mice inoculated with a murine isolate from the family Lachnospiraceae.
Infect Immun. 2012 Nov;80(11):3786-94. doi: 10.1128/IAI.00647-12. Epub 2012 Aug 13.
4
Burden of Clostridium difficile on the healthcare system.
Clin Infect Dis. 2012 Aug;55 Suppl 2(Suppl 2):S88-92. doi: 10.1093/cid/cis335.
5
Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin.
Clin Infect Dis. 2012 Aug;55 Suppl 2(Suppl 2):S104-9. doi: 10.1093/cid/cis357.
6
The Clostridium difficile spo0A gene is a persistence and transmission factor.
Infect Immun. 2012 Aug;80(8):2704-11. doi: 10.1128/IAI.00147-12. Epub 2012 May 21.
7
Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance.
Trends Microbiol. 2012 Jul;20(7):313-9. doi: 10.1016/j.tim.2012.04.001. Epub 2012 May 15.
8
Models for the study of Clostridium difficile infection.
Gut Microbes. 2012 Mar-Apr;3(2):145-67. doi: 10.4161/gmic.19526. Epub 2012 Mar 1.
9
Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection.
Clin Infect Dis. 2011 Nov;53(10):994-1002. doi: 10.1093/cid/cir632.
10
Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms.
Am J Infect Control. 2012 Aug;40(6):556-8. doi: 10.1016/j.ajic.2011.08.002. Epub 2011 Oct 7.
Zotero 插件