通过同源重组修复链断裂。
Repair of strand breaks by homologous recombination.
作者信息
Jasin Maria, Rothstein Rodney
机构信息
Developmental Biology Program, Memorial Sloan-Kettering Cancer Center New York, New York 10065.
出版信息
Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012740. doi: 10.1101/cshperspect.a012740.
Abstract
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.
摘要
在本综述中，我们讨论利用同源DNA序列修复DNA双链断裂（DSB，即同源重组[HR]），主要聚焦于酵母和哺乳动物。我们为当前对同源重组的观点提供了历史背景，并描述了在同源重组过程中双链断裂是如何被处理的，以及与其他双链断裂修复途径的相互作用。我们讨论了该过程的酶学，随后是对活细胞中双链断裂修复的研究。只要有可能，我们会引用原始文章和综述，以帮助读者进行进一步研究。
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