国际药理学联合会/英国药理学学会药物靶点和配体百科全书：一个由专家驱动的药物靶点和配体知识库。
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands.
机构信息
The University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK, School of Biomedical Sciences, Life Sciences E Floor, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK, Laboratory for Foundations of Computer Science, School of Informatics, 10 Crichton Street, University of Edinburgh, Edinburgh EH8 9AB, UK, Clinical Pharmacology Unit, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK, School of Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK, Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK and Spedding Research Solutions SARL, 6 Rue Ampere, Le Vésinet 78110, France.
出版信息
Nucleic Acids Res. 2014 Jan;42(Database issue):D1098-106. doi: 10.1093/nar/gkt1143. Epub 2013 Nov 14.
The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the ∼6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques.
国际药理学联合会/英国药理学会（IUPHAR/BPS）药理学指南（http://www.guidetopharmacology.org）是一个新的开放获取资源，提供了已批准和实验药物的靶点的药理学、化学、遗传、功能和病理生理学数据。该门户是在 IUPHAR 和 BPS 的支持下创建的，提供了广泛的已建立和潜在药物靶点的关键特性的简明、同行评审概述，并为重要靶点的子集提供了深入信息。该资源是 IUPHAR 数据库（IUPHAR-DB）和已发布的 BPS“受体和通道指南”（GRAC）丛书中的数据整理和整合的结果。这些数据来自全球专家贡献者网络，信息与相关数据库（包括 ChEMBL、DrugBank、Ensembl、PubChem、UniProt 和 PubMed）广泛链接。约 6000 种小分子和肽配体中的每一种都用手动注释的二维化学结构或氨基酸序列、命名法和数据库链接进行注释。该资源的未来扩展将完成对所有已批准药物和未来候选药物靶点的覆盖，同时还提供教育资源，指导科学家和学生了解药理学原理和技术。
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