神经胶质瘤干细胞在神经胶质瘤肿瘤发生中的作用。
The role of glioma stem cells in glioma tumorigenesis.
机构信息
Department of Emergency, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba Area, Chongqing 400038, China.
Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
出版信息
Front Biosci (Landmark Ed). 2014 Jan 1;19(5):818-24. doi: 10.2741/4249.
Malignant gliomas, the most common type of primary brain tumor, account for 80% of malignant tumors in the central nervous system (CNS). There are three principal types of glioma: astrocytomas, oligodendrogliomas, and oligoastrocytomas. Glioma stem cells (GSCs) have been found in all types; however, many fundamental questions about GSCs remain unanswered. This review will examine the current state of knowledge regarding GSC origin and the signaling pathways implicated in GSC tumorigenesis. The outstanding challenges for the study of GSCs in the context of glioma progression will also be discussed.
恶性胶质瘤是最常见的原发性脑肿瘤，占中枢神经系统（CNS）恶性肿瘤的 80%。胶质瘤主要有三种类型：星形细胞瘤、少突胶质细胞瘤和少突星形细胞瘤。所有类型的胶质瘤中都发现有胶质瘤干细胞（GSCs）；然而，关于 GSCs 的许多基本问题仍未得到解答。这篇综述将探讨 GSC 起源的当前知识状态以及涉及 GSC 肿瘤发生的信号通路。还将讨论在胶质瘤进展的背景下研究 GSCs 所面临的突出挑战。
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