通过翻译后的内容可以看出，译文语言流畅，语法正确，能够准确表达原文的意思。 - 译文在“protein stability”翻译为“蛋白质稳定性”，是一种常用的翻译方法，能够准确传达原文的意思。 - “post-translational modifications”翻译为“翻译后修饰”，这种翻译方法能够准确传达原文的意思，同时也符合中文的表达习惯。 - “DNA methyltransferase 1”翻译为“DNA 甲基转移酶 1”，这种翻译方法能够准确传达原文的意思，同时也符合中文的表达习惯。
Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.
机构信息
Department of Genetics and Genome Sciences, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
Acta Biochim Biophys Sin (Shanghai). 2014 Mar;46(3):199-203. doi: 10.1093/abbs/gmt146. Epub 2014 Jan 3.
Abstract
DNA methylation is an important epigenetic mechanism that ensures correct gene expression and maintains genetic stability. DNA methyltransferase 1 (DNMT1) is the primary enzyme that maintains DNA methylation during replication. Dysregulation of DNMT1 is implicated in a variety of diseases. DNMT1 protein stability is regulated via various post-translational modifications, such as acetylation and ubiquitination, but also through protein-protein interactions. These mechanisms ensure DNMT1 is properly activated during the correct time of the cell cycle and at correct genomic loci, as well as in response to appropriate extracellular cues. Further understanding of these regulatory mechanisms may help to design novel therapeutic approaches for human diseases.
摘要
DNA 甲基化是一种重要的表观遗传机制，可确保正确的基因表达并维持遗传稳定性。DNA 甲基转移酶 1（DNMT1）是复制过程中维持 DNA 甲基化的主要酶。DNMT1 的失调与多种疾病有关。DNMT1 蛋白稳定性通过各种翻译后修饰（如乙酰化和泛素化）以及通过蛋白质-蛋白质相互作用来调节。这些机制可确保 DNMT1 在细胞周期的正确时间以及在正确的基因组位置处，并响应适当的细胞外信号而被正确激活。进一步了解这些调控机制可能有助于为人类疾病设计新的治疗方法。
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