肠内微生物群与先天淋巴细胞的相互作用。
Interactions between the intestinal microbiota and innate lymphoid cells.
机构信息
Department of Microbiology and Immunobiology; Harvard Medical School; Boston, MA USA.
出版信息
Gut Microbes. 2014 Jan-Feb;5(1):129-40. doi: 10.4161/gmic.27289. Epub 2013 Dec 16.
Abstract
The mammalian intestine must manage to contain 100 trillion intestinal bacteria without inducing inappropriate immune responses to these microorganisms. The effects of the immune system on intestinal microorganisms are numerous and well-characterized, and recent research has determined that the microbiota influences the intestinal immune system as well. In this review, we first discuss the intestinal immune system and its role in containing and maintaining tolerance to commensal organisms. We next introduce a category of immune cells, the innate lymphoid cells, and describe their classification and function in intestinal immunology. Finally, we discuss the effects of the intestinal microbiota on innate lymphoid cells.
摘要
哺乳动物的肠道必须容纳 100 万亿肠道细菌，而不能对这些微生物产生不适当的免疫反应。免疫系统对肠道微生物的影响是众多且特征明确的，最近的研究已经确定，微生物群也会影响肠道免疫系统。在这篇综述中，我们首先讨论肠道免疫系统及其在容纳和维持对共生生物的耐受性方面的作用。接下来，我们介绍一类免疫细胞，即先天淋巴细胞，并描述其在肠道免疫学中的分类和功能。最后，我们讨论了肠道微生物群对先天淋巴细胞的影响。
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本文引用的文献
1
A maternal vaccine against group B Streptococcus: past, present, and future.
Vaccine. 2013 Aug 28;31 Suppl 4(0 4):D13-9. doi: 10.1016/j.vaccine.2012.12.080.
2
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.
Nature. 2013 Aug 8;500(7461):232-6. doi: 10.1038/nature12331. Epub 2013 Jul 10.
3
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.
Science. 2013 Aug 2;341(6145):569-73. doi: 10.1126/science.1241165. Epub 2013 Jul 4.
4
RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44.
Immunity. 2013 Jun 27;38(6):1223-35. doi: 10.1016/j.immuni.2013.05.013. Epub 2013 Jun 20.
5
Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection.
PLoS One. 2013 Jun 4;8(6):e65405. doi: 10.1371/journal.pone.0065405. Print 2013.
6
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.
Nature. 2013 Jun 6;498(7452):113-7. doi: 10.1038/nature12240. Epub 2013 May 22.
7
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
N Engl J Med. 2013 Apr 25;368(17):1575-84. doi: 10.1056/NEJMoa1109400.
8
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
J Exp Med. 2013 May 6;210(5):917-31. doi: 10.1084/jem.20122308.
9
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.
Immunity. 2013 Apr 18;38(4):769-81. doi: 10.1016/j.immuni.2013.02.010. Epub 2013 Feb 28.
10
Innate lymphoid cells--a proposal for uniform nomenclature.
Nat Rev Immunol. 2013 Feb;13(2):145-9. doi: 10.1038/nri3365.
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