基于二茂铁-芘的“开环”化学比色传感器用于 Cr(3+)-的生物成像应用。
A ferrocene-pyrene based 'turn-on' chemodosimeter for Cr(3+)- application in bioimaging.
机构信息
Department of Chemistry, UGC-Center for Advanced Studies-I, Guru Nanak Dev University, Amritsar-143 005, Punjab, India.
出版信息
Dalton Trans. 2014 Apr 21;43(15):5707-12. doi: 10.1039/c3dt53536c. Epub 2014 Feb 20.
PMID:24553910
Abstract
Structurally simple, ferrocene-pyrene imine dyad 1 has been developed as a 'turn-on' chemodosimeter for Cr(3+). The sensing event is based upon the hydrolysis of the imine functionality. Further, 1, which is also non-cytotoxic (100% cell viability), detects intracellular Cr(3+) in the human breast cancer (MCF-7) cells.
摘要
开发了结构简单的二茂铁-芘亚胺偶联物 1，作为 Cr(3+)的“开启”型比色化学传感器。该传感事件基于亚胺官能团的水解。此外，1 还具有非细胞毒性（细胞活力 100%），可检测人乳腺癌（MCF-7）细胞内的 Cr(3+)。
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