稠合吡唑衍生物的合成进展（2010年至2013年年中）
Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013).
作者信息
Li Meng, Zhao Bao-Xiang
机构信息
Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
出版信息
Eur J Med Chem. 2014 Oct 6;85:311-40. doi: 10.1016/j.ejmech.2014.07.102. Epub 2014 Aug 5.
Condensed pyrazole derivatives are important heterocyclic compounds due to their excellent biological activities and have been widely applied in pharmaceutical and agromedical fields. In recent years, numerous condensed pyrazole derivatives have been synthesized and advanced to clinic studies with various biological activities. In this review, we summarized the reported synthesis methods of condensed pyrazole derivatives from 2010 until now. All compounds are divided into three parts according to the rings connected to pyrazole-ring, i.e. [5, 5], [5,F 6], and [5, 7]-condensed pyrazole derivatives. The biological activities and applications in pharmaceutical fields are briefly introduced to offer an orientation for the design and synthesis of condensed pyrazole derivatives with good biological activities.
稠合吡唑衍生物因其优异的生物活性而成为重要的杂环化合物，并已广泛应用于制药和农业医学领域。近年来，众多稠合吡唑衍生物已被合成并推进到具有各种生物活性的临床研究中。在本综述中，我们总结了2010年至今报道的稠合吡唑衍生物的合成方法。所有化合物根据与吡唑环相连的环分为三部分，即[5,5]、[5,6]和[5,7]稠合吡唑衍生物。简要介绍了其生物活性及在制药领域的应用，为设计和合成具有良好生物活性的稠合吡唑衍生物提供指导。
Zotero 插件